Environmental health science in the city by the Bay.
نویسنده
چکیده
The present investigation shows the effect of vitamin A deficiency on the initiation and postinitiation phases of benzo(a)pyrene-induced lung carcinogenesis in male Wistar rats. Lung tumours were induced by giving three intratracheal instillations, one week apart, of 10mg benzo(a)pyrene per instillation. Maximum tumour incidence (100%) and tumour burden per rat was found in rats which were kept on vitamin A deficient diet for 4 weeks prior to the first administration and 8 weeks after the last administration of benzo(a)pyrene. Rats in which vitamin A deficiency was terminated after the last administration of the carcinogen had 83% tumour incidence, whereas corresponding control pairfed animals had 39% incidence of tumours. These data represent the values obtained 32 weeks after the last administered dose of the carcinogen and indicate the role of vitamin A, both in the initiation as well as in the postinitiation phases of lung
منابع مشابه
Ecological Problems of Gorgan Bay in the Southeast Corner of the Caspian Sea (Iran) and Ways of Improvement
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ورودعنوان ژورنال:
- Environmental Health Perspectives
دوره 103 شماره
صفحات -
تاریخ انتشار 1995